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No.

Authors
Journal, Book
DOI

Title

Involved Partners

Year

77

Lome V, Brunel JM, Pagès J-M, Bolla JM.
N.N

Multiparametric profiling for chemosensitizers identification against Gram-negative bacteria

AMU

2017 in revision

76

Heng-Keat Tam, Viveka Nand Malviya and Klaas M. Pos
in Bacterial Multidrug Exporters, of the series Methods in Molecular Biology, Ed. A. Yamaguchi (Springer Verlag, Heidelberg, New York).

High resolution crystallographic analysis of AcrB using Designed Ankyrin Repeat Proteins (DARPins)

GUF

2017 in press

75

Cacciotto P, Ramaswamy VK, Malloci G, Ruggerone P, Vargiu AV
in Bacterial Multidrug Exporters, of the series Methods in Molecular Biology, Ed. A. Yamaguchi (Springer Verlag, Heidelberg, New York).

Molecular modeling of multi-drug properties of RND transporters

UNICA

2017 in press

74

A. Allam, L. Maigre, J. Vergalli, E. Dumont, B. Cinquin, R. Alves de Souza, E. Pinet, N. Smith, J-P. Herbeuval, M. Réfregiers, I. Artaud, J-M. Pagès
Scientific Report

Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

AMU, SYN

2017 in press

73

Naresh Niranjan Dhanasekar, Soumeya Aliouane, Mathias Winterhalter, Jean-Marie Pagès, Jean-Michel Bolla
Biochemistry and Biophysics Reports

Peptide translocation across MOMP, the major outer membrane channel from Campylobacter jejuni

JUB, AMU

2017 in press

72

Noémie Mayer, Suzanne Bialek-Davenet, Julia Vergalli, Sylvain Brisse, Jean-Marie Pagès, Marie-Hélène Nicolas-Chanoine

Up and down regulation of PhoE modulate the carbapenem resistance in Klebsiella pneumoniae clinical isolates with inactivated OmpK porins

APHP-BUH, AMU

2017 in prep

71

Noémie Mayer, Kathleen Guyot, Estelle Dumont, Thomas  Guillard, Jean-Marie Pagès, Jean Yves Madec, Marie-Hélène Nicolas-Chanoine

Deciphering the impact of efflux pump and porin expression on acquired resistance to old and new antibiotics in 45 isogenic strains of Klebsiella pneumoniae

APHP-BUH, AMU

2017 in prep

70

Soundararajan, Gowrishankar; Bhamidimarri, Satya Prathyusha; Winterhalter, Mathias
ACS Chemical Biology, 2017

Understanding carbapenem translocation through OccD3 (OpdP) of Pseudomonas aeruginosa.

JUB

2017 in prep

69

Pothula, Karunakar; Dhanasekar, Naresh; Lamichhane, Usha; Younas, Farhan; Pletzer, Daniel; Benz, Roland; Winterhalter, Mathias; Kleinekathöfer, Ulrich
J. Phys. Chem. B, 2017, 121 (12), pp 2614–2621
DOI: 10.1021/acs.jpcb.7b01787

A Single Residue Acts as Gate in OccK Channels

JUB

2017

68

Ghai, Ishan; Pira, Alessandro; Scorciapino, Mariano; Bodrenko, Igor; Benier, Lorraine; Ceccarelli, Matteo; Winterhalter, Mathias; Wagner, Richard
The Journal of Physical Chemistry Letters
DOI: 10.1021/acs.jpclett.7b00062

A General Method to Determine the Flux of Charged Molecules Through Nanopores Applied to ß-Lactamase Inhibitors and OmpF

JUB, UNICA

2017

67

Muriel Masi, Matthieu Refregiers, Klaas M. Pos, Jean-Marie Pages
Nature Microbiology
DOI: 10.1038/nmicrobiol.2017.1

Mechanisms of envelope permeability and antibiotic efflux in Gram-negative bacteria

AMU, SYN, GUF

2017

66

Ishan Ghai, Mathias Winterhalter, Richard Wagner
Biochemical and Biophysical Research Communications. Volume 484, Issue 1, 26 February 2017, Pages 51–55
DOI: 10.1016/j.bbrc.2017.01.076

Probing transport of charged ß-lactamase inhibitors through OmpC, a membrane channel from E. coli

JUB, ION

2017

65

Glenwright AJ, Pothula KR, Bhamidimarri SP, Chorev DS, Baslé A, Firbank SJ, Zheng H, Robinson CV, Winterhalter M, Kleinekathöfer U, Bolam DN, van den Berg B.
Nature
DOI: 10.1038/nature20828

Structural basis for nutrient acquisition by dominant members of the human gut microbiota.

JUB, NEW

2017

64

Mariano Andrea Scorciapino, Silvia Acosta-Gutierrez, Dehbia Benkerrou, Tommaso D’Agostino, Giuliano Malloci, Susruta Samanta, Igor Bodrenko, Matteo Ceccarelli
Journal of Physics: Condensed Matter 1–16
DOI: 10.1088/1361-648X/aa543b

Rationalizing the permeation of polar antibiotics into Gram-negative bacteria

UNICA

2017

63

Harsha Bajaj, Silvia Acosta Gutierrez, Igor Bodrenko, Giuliano Malloci, Mariano Andrea Scorciapino, Mathias Winterhalter, and Matteo Ceccarelli
ACS Nano
DOI: 10.1021/acsnano.6b08613

Bacterial Outer Membrane Porins as Electrostatic Nanosieves: Exploring Transport Rules of Small Polar Molecules

UNICA, JUB

2017

62

Allam A, Maigre L, Alves de Sousa R, Dumont E, Vergalli J, Pagès J-M, Artaud I.
Eur J Med Chem. 2016 Oct 25. pii: S0223-5234(16)30916-3.
DOI: 10.1016/j.ejmech.2016.10.054

New amphiphilic neamine conjugates bearing a metal binding motif active against MDR E. aerogenes Gram-negative bacteria

AMU, SYN

2016

61

Schuster S, Vavra M, Kern W
Antimicrob Agent Chemother
DOI: 10.1128/AAC.00314-16

Evidence of a substrate discriminating entrance channel in the lower porter domain of the multidrug resistance efflux pump AcrB

UKL-FR

2016

60

Ramaswamy VK, Cacciotto P, Malloci G, Ruggerone P, Vargiu AV
in Efflux-Mediated Drug Resistance in Bacteria: Mechanisms, Regulation and Clinical Implications, Eds. Xian-Zhi Li, Christopher A. Elkins and Helen I. Zgurskaya (Springer International Publishing).
DOI: 10.1007/978-3-319-39658-3_30

Multidrug efflux pumps and their inhibitors characterized by computational modeling

UNICA

2016

59

Wanatchaporn Arunmanee, Monisha Pathania, Alexandra Soloyova, Anton P. Le Brun, Helen Ridley, Arnaud Baslé, Bert van den Berg and Jeremy H. Lakey
PNAS, Volume113, no. 34
DOI: 10.1073/pnas.1602382113

Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis

NEW

2016

58

Vaas LAI, Witt G, Windshügel B, Bosin A, Serra G, Bruengger A, Winterhalter M, Gribbon P, Levy-Petelinkar CJ, Kohler M
PeerJ Computer Science 2:e83
DOI: 10.7717/peerj-cs.83

Electronic laboratory notebooks in a public-private-partnership

IME-SP, UNICA, JUB, BASILEA, GSK

2016

57

Charles Auffray, Rudi Balling, Inês Barroso, et.al.
Genome Medicine 20168:71
DOI: 10.1186/s13073-016-0323-y

Making sense of big data in health research: Towards a European Union action plan

IME-SP

2016

56

K. R. Pothula, C. J. Solano and U. Kleinekathöfer
Biochimica et Biophysica Acta (BBA) – Biomembranes
DOI: 10.1016/j.bbamem.2015.12.020

Simulations of outer membrane channels and their permeability

JUB

2016

55

Tommaso D’Agostino, Samuele Salis, and Matteo Ceccarelli
BBA-Biomembranes 2016
DOI: 10.1016/j.bbamem.2016.01.004

A Kinetic Model for Molecular Diffusion through Pores

UNICA

2016

54

P. Bhamidimarri, J. D. Prajapati, B. van den Berg, M. Winterhalter and U. Kleinekathöfer
Biophys. J. 110, 600–611
DOI: 10.1016/j.bpj.2015.12.027

Role of Electroosmosis in the Permeation of Neutral Molecules: CymA and Cyclodextrin as an Example

JUB, NEW

2016

53

I Lytvynenko, S Brill, C Oswald, KM Pos
J Mol Biol, Volume 428, Issue 3, 644–657
DOI: 10.1016/j.jmb.2015.12.006

Molecular basis of polyspecificity of the Small Multidrug Resistance Efflux Pump AbeS from Acinetobacter baumannii

GUF

2016

52

Zahn M, Bhamidimarri SP, Baslé A, Winterhalter M, van den Berg B.
Structure. (2016) 24:221-31
DOI: 10.1016/j.str.2015.12.009

Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii

NEW, JUB

2016

51

Daury L, Orange F, Taveau JC, Verchère A, Monlezun L, Gounou C, Marreddy RK, Picard M, Broutin I, Pos KM, Lambert O
Nat Commun 7: 10731
DOI: 10.1038/ncomms10731

Tripartite assembly of RND multidrug efflux pumps

GUF

2016

50

Acosta-Gutierrez Silvia, Igor Bodrenko, Mariano Andrea Scorciapino, and Matteo Ceccarelli
Physical Chemistry Chemical Physics, 2016
DOI: 10.1039/C5CP07902K

Macroscopic electric field inside water-filled biological nanopores

UNICA

2016

49

Kinana AD, Vargiu AV, May T, Nikaido H
Proc Natl Acad Sci USA 113(5): 1405-10
DOI: 10.1073/pnas.1525143113

Aminoacyl ß-naphthylamides as substrates and modulators of AcrB multidrug efflux pump

UNICA

2016

48

Sjuts H, Vargiu AV, Kwasny SM, Nguyen ST, Kim HS, Ding X, Ornik AR1, Ruggerone P, Bowlin TL, Nikaido H, Pos KM, Opperman TJ
Proc Natl Acad Sci USA 113(13): 3509-14
DOI: 10.1073/pnas.1602472113

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

UNICA, GUF

2016

47

Harsha Bajaj, Mariano A. Scorciapino, Lucile Moynie, Malcolm G. P. Page, James H. Naismith, Matteo Ceccarelli, and Mathias Winterhalter
J. Biol. Chem. 291 (2016) 2837-47
DOI: 10.1074/jbc.M115.690156

Molecular Basis of Filtering Carbapenems by Porins from ß-Lactam-resistant Clinical Strains of Escherichia coli

JUB, UNICA, USTAN, BASILEA

2016

46

Kostyanev, T; Bonten, M; O'Brien, S; Steel, H; Ross, S; François, B; Tacconelli, E; Winterhalter, M; Stavenger, R; Karlén, A; Harbarth, S; Hackett, J; Jafri, H; Cuong, V; MacGowan, A; Witschi, A; Angyalosi, G; Elborn, S; deWinter, R; Goossens, H
J. Antimicrob. Chemother. 71 (2): 290-295
DOI: 10.1093/jac/dkv339

The Innovative Medicines Initiative's New Drugs for Bad Bugs programme – European public-private partnerships for the development of new strategies to tackle antibiotic resistance

GSK, JUB

2016

45

Bohnert JA, Schuster S, Kern WV, Karcz T, Olejarz A, Kaczor A, Handzlik J, Kiec-Kononowicz K
Antimicrob Agents Chemother 60(4): 1974-83
DOI: 10.1128/AAC.01995-15

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay

UKL-FR

2016

44

Vargiu AV, Pos KM, Poole K, Nikaido H
Front Microbiol 7: 833
DOI: 10.3389/fmicb.2016.00833

Bad bugs in the XXIst century: resistance mediated by multi-drug efflux pumps in Gram-negative bacteria

UNICA, GUF

2016

43

Malloci G, Serra G, Bosin A, Vargiu AV
Computation 4: 5
DOI: 10.3390/computation4010005

Extracting Conformational Ensembles of Small Molecules from Molecular Dynamics Simulations: Ampicillin As A Test Case

UNICA

2016

42

Gasser V, Baco E, Cunrath O, August PS, Perraud Q, Zill N, Schleberger C, Schmidt A, Paulen A, Bumann D, Mislin GL, Schalk IJ.
Environ Microbiol. 2016 Mar;18(3):819-32.
DOI: 10.1111/1462-2920.13199

Catechol siderophores repress the pyochelin pathway and activate the enterobactin pathway in Pseudomonas aeruginosa: an opportunity for siderophore-antibiotic conjugates development

CNRS, UNIBAS

2016

41

Oswald, C., Tam, H-K., Pos, K. M.
Nat. Commun. 7: 13819
DOI: 10.1038/ncomms13819

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

GUF

2016

40

Luana G M Ferrara, Gregor D Wallat, Lucile Moynié, Naresh Niranjan Dhanasekar, Mathias Winterhalter, Jean-Michel Bolla, Soumeya Aliouane, Jean-Marie Pagès, Silvia Acosta-Gutiérrez, Matteo Ceccarelli, James H Naismith
Journal of Molecular Biology 428, no. 22 (November 6, 2016): 4528–43.
DOI: 10.1016/j.jmb.2016.09.021

MOMP From Campylobacter Jejuni Is a Trimer of 18-Stranded ß-Barrel Monomers with a Ca(2+) Ion Bound at the Constriction Zone.

NEW, JUB, AMU, UNICA

2016

39

Scorciapino, M. A. et al.
Future Med Chem 8, 1047–1062 (2016).
DOI: 10.4155/fmc-2016-0038

Exploiting the porin pathway for polar compound delivery into Gram-negative bacteria.

UNICA

2016

38

N. Modi, S. Ganguly, I. Bárcena-Uribarri, R. Benz, B. van den Berg and U. Kleinekathöfer
Biophys. J. 109, 1429–1438
DOI: 10.1016/j.bpj.2015.07.035

Structure, Dynamics, and Substrate Specificity of the OprO Porin from Pseudomonas aeruginosa

JUB, NEW

2015

37

Isabella, Vincent M.; Campbell, Arthur J.; Manchester, John; et al.
CHEMISTRY & BIOLOGY 22: 535-547
DOI: 10.1016/j.chembiol.2015.03.018

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

AZ

2015

36

Winterhalter M, Ceccarelli M
Eur J Pharm Biopharm. 95, 63-7
DOI: 10.1016/j.ejpb.2015.05.006

Physical methods to quantify small antibiotic molecules uptake into Gram-negative bacteria

JUB, UNICA

2015

35

Zahn M, D'Agostino T, Eren E, Baslé A, Ceccarelli M, van den Berg B.
J Mol Biol. 427:2329-39
DOI: 10.1016/j.jmb.2015.03.016

Small-Molecule Transport by CarO, an Abundant Eight-Stranded ß-Barrel Outer Membrane Protein from Acinetobacter baumannii

UNICA, NEW

2015

34

Du, D., van Veen, H.W., Murakami, S., Pos, K. M. and Luisi, B.
Curr. Opinion Struc. Biol. 33: 76-91
DOI: 10.1016/j.sbi.2015.07.015

Structure, mechanism and cooperation of bacterial multidrug efflux transporters

GUF

2015

33

Zhou Y, Joubran C, Miller-Vedam L, Vincent I, Nayar A, Tentarelli S, Miller A
Anal. Chem., 87 (7), pp 3579–3584
DOI: 10.1021/ac504880r

Thinking Outside the "Bug": A Unique Assay To Measure Intracellular Drug Penetration in Gram-Negative Bacteria

AZ

2015

32

Acosta-Gutierrez S, Scorciapino M, Mariano A, Bodrenko I, and Matteo Ceccarelli
J. Phys. Chem. Lett., 6 (10), pp 1807–1812
DOI: 10.1021/acs.jpclett.5b00612

Filtering with Electric Field: The Case of E. coli Porins

UNICA

2015

31

Niraj Modi, Ivan Barcena Uribarri, Manjeet Bains, Roland Benz, Robert Hancock, Ulrich Kleinekathoefer
ACS Chemical Biology 10: 441-51
DOI: 10.1021/cb500399j

Tuning the affinity of anion binding sites in porin channels with negatively charged residues: Molecular details for OprP

JUB

2015

30

Cama J, Bajaj H, Pagliara S, Maier T, Braun Y, Winterhalter M, Keyser UF.
J. Am. Chem. Soc., 137, 13836–13843
DOI: 10.1021/jacs.5b08960

Quantification of Fluoroquinolone Uptake through the Outer Membrane Channel OmpF of Escherichia coli

JUB

2015

29

Gutsmann T, Heimburg T, Keyser U, Mahendran KR, Winterhalter M.
Nat Protoc. 10:188-98
DOI: 10.1038/nprot.2015.003

Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization

JUB

2015

28

Van den Berg B, Prathyusha Bhamidimarri S, Winterhalter M
Sci. Report, 5, 11927
DOI: 10.1038/srep11927

Crystal structure of a COG4313 outer membrane channel

NEW, JUB

2015

27

B. Cinquin, L. Maigre, E. Pinet, J. Chevalier, R. A. Stavenger, S. Mills, M. Réfregiers and J.-M. Pagès
Sci. Rep. 5:17968
DOI: 10.1038/srep17968

Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level

AMU, SYN, GSK, AZ

2015

26

Bodrenko I, Bajaj H, Ruggerone P, Winterhalter M, Ceccarelli M.
Analyst. 140:4820-7
DOI: 10.1039/c4an02293a

Analysis of fast channel blockage: revealing substrate binding in the microsecond range

UNICA, JUB

2015

25

Weichbrodt C, Bajaj H, Baaken G, Wang J, Guinot S, Kreir M, Behrends JC, Winterhalter M, Fertig N.
Analyst. 140:4874-81
DOI: 10.1039/c4an02335h

Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms

NAN, JUB

2015

24

Pothula, R, Kleinekathöfer, U.
Analyst. 140:4855-64
DOI: 10.1039/C5AN00036J

Theoretical analysis of ion conductance and gating transitions in the OpdK (OccK1) channel

JUB

2015

23

Samanta, Susruta, Mariano Andrea Scorciapino, and Matteo Ceccarelli
Physical Chemistry Chemical Physics, PCCP 17, 23867–76
DOI: 10.1039/C5CP02844B

Molecular Basis of Substrate Translocation Through the Outer Membrane Channel OprD of Pseudomonas Aeruginosa

UNICA

2015

22

Paulen A, Gasser V, Hoegy F, Perraud Q, Pesset B, Schalk IJ, Mislin GLA
Org. Biomol. Chem., 13, 11567-11579
DOI: 10.1039/C5OB01859E

Synthesis and antibiotic activity of oxazolidinone-catechol conjugates against Pseudomonas aeruginosa

CNRS

2015

21

van den Berg B, Prathyusha Bhamidimarri S, Dahyabhai Prajapati J, Kleinekathöfer U, Winterhalter M.
Proc Natl Acad Sci U S A. 112:E2991-9
DOI: 10.1073/pnas.1424835112

Outer-membrane translocation of bulky small molecules by passive diffusion

JUB, NEW

2015

20

Périamé M, Philippe N, Condell O, Fanning S, Pagès JM, Davin-Regli A
Lett Appl Microbiol.
DOI: 10.1111/lam.12435

Phenotypic changes contributing to Enterobacter gergoviae biocide resistance

AMU, UCD

2015

19

Pletzer D, Braun Y, Dubiley S, Lafon C, Köhler T, Page MGP, Mourez M, Severinov K, Weingart H
J Bacteriol 197:2217–222
DOI: 10.1128/JB.00234-15

The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics

JUB, UGE, BASILEA, SARD

2015

18

Schulz R, Vargiu AV, Ruggerone P, Kleinekathöfer U.
Biomed Res Int. 487298
DOI: 10.1155/2015/487298

Computational study of correlated domain motions in the AcrB efflux transporter

UNICA, JUB

2015

17

Philippe N, Maigre L, Santini S, Pinet E, Claverie JM, Davin-Regli A, Pagès JM, Masi M
PLOS ONE. 2015 Sep 23;10(9):e0138828
DOI: 10.1371/journal.pone.0138828

In vivo evolution of bacterial resistance in two cases of Enterobacter aerogenes infections during treatment with imipenem

AMU

2015

16

Benz R., Jones M.D., Younas F., Maier E., Modi N., Mentele R., Lottspeich F., Kleinekathöfer U., and Smit J.
PLoS One
DOI: 10.1371/journal.pone.0143557

OmpW of Caulobacter crescentus functions as an outer membrane channel for cations

JUB

2015

15

Müller R. T., Pos K. M.
Biol Chem. 396(9-10):1083-9
DOI: 10.1515/hsz-2015-0150

The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump

GUF

2015

14

Davin-Regli A, Pagès JM
Front Microbiol. 6:392
DOI: 10.3389/fmicb.2015.00392

Enterobacter aerogenes and Enterobacter cloacae; versatile bacterial pathogens confronting antibiotic treatment

AMU

2015

13

Dreier J and Ruggerone P
Front Microbiol 6: 660
DOI: 10.3389/fmicb.2015.00660

Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa

BASILEA, UNICA

2015

12

Malloci, G.; Vargiu, A.V.; Serra, G.; Bosin, A.; Ruggerone, P.; Ceccarelli, M.
Molecules 2015, 20, 13997-14021
DOI: 10.3390/molecules200813997

A Database of Force-Field Parameters, Dynamics, and Properties of Antimicrobial Compounds

UNICA

2015

11

Cha, H., Pos KM; Ed. Krämer, R. and Ziegler, C.
Chapter 9: 207-232
DOI: 10.1007/978-3-642-53839-1_9

Cooperative transport mechanism and proton-coupling in the multidrug efflux transporter complex AcrAB-TolC. Membrane Transport Mechanism – 3D structure and beyond

GUF

2014

10

G.L.A. Mislin and I.J. Schalk
Metallomics 6, 408-420
DOI: 10.1039/c3mt00359k

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa

CNRS

2014

9

E. Baco, F. Hoegy, I.J. Schalk and Gaëtan L. A. Mislin
Org. Biomol. Chem. 12, 749-757
DOI: 10.1039/C3OB41990H

Diphenyl-benzo[1, 3]dioxole-4-carboxylic acid pentafluorophenyl ester: a convenient catechol precursor in the synthesis of siderophore vectors suitable for antibiotic Trojan horse strategies

CNRS

2014

8

Bialek-Davenet S, Lavigne JP, Guyot K, Mayer N, Tournebize R, Brisse S, Leflon-Guibout V, Nicolas-Chanoine MH.
J. Antimicrob. Chemother.
DOI: 10.1093/jac/dku340

Differential contribution of AcrAB and OqxAB efflux pumps to multidrug resistance and virulence in Klebsiella pneumonia

APHP-BUH

2014

7

Stavenger RA, Winterhalter M
Sci. Transl. Med. 6:228ed7
DOI: 10.1126/scitranslmed.3008605

TRANSLOCATION project: how to get good drugs into bad bugs

JUB, GSK

2014

6

Cha, H., Müller, RT, Pos, KM
Antimicrob. Agents Chemother. 58:4767-4772
DOI: 10.1128/AAC.02733-13

Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter

GUF

2014

5

Daniel Pletzer, Corinne Lafon, Yvonne Braun, Thilo Köhler, Malcolm G. P. Page, Michael Mourez, Helge Weingart
PLOS ONE
DOI: 10.1371/journal.pone.0111311

High-Throughput Screening of Dipeptide Utilization Mediated by the ABC Transporter DppBCDF and its Substrate-binding Proteins DppA1-A5 in Pseudomonas aeruginosa

JUB, UGE, AMU, SARD

2014

4

Eicher, T, Seeger, MA, Anselmi, C, Zhou, W, Brandstätter, L, Verrey, F, Diederichs, K, Faraldo-Gómez, JD, Pos, KM
eLife 3:e03145
DOI: 10.7554/eLife.03145

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump

GUF

2014

3

N. Modi, I. Bárcena-Uribarri, M. Bains, R. Benz, R.E.W. Hancock, and U. Kleinekathöfer
Biochemistry 52, 5522-5532
DOI: 10.1021/bi400522b

Role of the central arginine R133 towards the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation

JUB

2013

2

J. Lu, N. Modi, and U. Kleinekathöfer
J. Phys. Chem. B, 117 (50), pp 15966–15975
DOI: 10.1021/jp408495v

Simulation of Ion Transport Through an N-acetylneuraminic Acid-inducible Membrane Channel: From Understanding to Engineering

JUB

2013

1

P. Ruggerone, S. Murakami, K. M. Pos, and A.V. Vargiu
Curr. Top. Med. Chem. 13, 3079-3100
DOI: 10.2174/15680266113136660220

RND Efflux Pumps: Structural Information Translated Into Function And Inhibition Mechanisms

UNICA, GUF

2013