TRANSLOCATION: Molecular basis of the bacterial cell wall permeability

In a wide, transdisciplinary research alliance, leading scientist from microbiology, structural biology as well as applied and computational biophysics are to examine, how antibiotic substances are transported across bacterial cell walls into the pathogens with the help of highly specialized transport proteins- so called porins. Through extensive screenings the researcherswill firstly identify the relevant prions to then analyze their structure and function in detail. Furthermore, the scientist will work on a better understanding of the mechanisms that bacteria use to flush out certain antibiotic molecules before they can be effective. The second key aspect of the project is to learn from previous success and failure, which in turn requires a large body of data from multiple sources. The creation of a cross-project information center and database as well as the development of the business model to support the sharing of data will offer access to new data from the results of all projects under the IMI AMR program. The TRANSLOCATION project team will coordinate the disclosure and combined analysis of previously confidential information, which is being provided primarily from participating companies of the European Federation of Pharmaceutical industries (EFPIA). Additionally, the team will help to coordinate the dissemination of information and knowledge.


Concept of the Research and Discovery aspects of TRANSLOCATION

Efficiency and Data Sharing aspects of TRANSLOCATION